Week 1
- Game: Indiana State at Purdue
- When: Saturday, Aug. 31
- Where: Ross-Ade Stadium in West Lafayette, Ind.
- Time: 12 p.m. ET
- TV: Big Ten Network
- Series record: Purdue leads the all-time series 6-0
- Last matchup: Purdue defeated Indiana State 56-0 on Sept. 10, 2022
Week 2
Purdue’s first bye week
Week 3
- Game: Notre Dame at Purdue
- When: Saturday, Sept. 14
- Where: Ross-Ade Stadium in West Lafayette, Ind.
- Time: 3:30 p.m. ET
- TV: CBS
- Series record: Notre Dame leads the all-time series 57-26-2
- Last matchup: Notre Dame defeated Purdue 27-13 on Sept. 18, 2021
Week 4
- Game: Purdue at Oregon State
- When: Saturday, Sept. 21
- Where: Reser Stadium in Corvallis, Ore.
- Time: 8:30 p.m. ET
- TV: CW Network
- Series record: Oregon State and Purdue are tied 1-1 in the all-time series
- Last matchup: Purdue defeated Oregon State 30-21 on Sept. 4, 2021
Week 5
- Game: Nebraska at Purdue
- When: Saturday, Sept. 28
- Where: Ross-Ade Stadium in West Lafayette, Ind.
- Time: 12 p.m. ET
- TV: To be determined
- Series record: Nebraska and Purdue are tied 6-6 in the all-time series
- Last matchup: Nebraska defeated Purdue 31-14 on Oct. 28, 2023
Week 6
- Game: Purdue at Wisconsin
- When: Saturday, Oct. 5
- Where: Camp Randall Stadium in Madison, Wis.
- Time: To be determined
- TV: To be determined
- Series record: Wisconsin leads the all-time series 53-29-8
- Last matchup: Wisconsin defeated Purdue 38-17 on Sept. 22, 2023
Week 7
- Game: Purdue at Illinois (Purdue Cannon game)
- When: Saturday, Oct. 12
- Where: Memorial Stadium in Champaign, Ill.
- Time: To be determined
- TV: To be determined
- Series record: Purdue leads the all-time series 48-45-6
- Last matchup: Purdue defeated Illinois 44-19 on Sept. 30, 2023
Week 8
- Game: Oregon at Purdue
- When: Friday, Oct. 18
- Where: Ross-Ade Stadium in West Lafayette, Ind.
- Time: 8 p.m. ET
- TV: FOX
- Series record: Oregon leads the all-time series 2-1
- Last matchup: Oregon defeated Purdue 38-36 on Sept. 12, 2009
Week 9
Purdue’s second bye week
Week 10
- Game: Northwestern at Purdue
- When: Saturday, Nov. 2
- Where: Ross-Ade Stadium in West Lafayette, Ind.
- Time: To be determined
- TV: To be determined
- Series record: Purdue leads the all-time series 53-34-1
- Last matchup: Northwestern defeated Purdue 23-15 on Nov. 18, 2023
Week 11
- Game: Purdue at Ohio State
- When: Saturday, Nov. 9
- Where: Ohio Stadium in Columbus, Ohio
- Time: To be determined
- TV: To be determined
- Series record: Ohio State leads the all-time series 41-15-2
- Last matchup: Ohio State defeated Purdue 41-7 on Oct. 14, 2023
Week 12
- Game: Penn State at Purdue
- When: Saturday, Nov. 16
- Where: Ross-Ade Stadium in West Lafayette, Ind.
- Time: To be determined
- TV: To be determined
- Series record: Penn State leads the all-time series 16-3-1
- Last matchup: Penn State defeated Purdue 35-31 on Sept. 1, 2022
Week 13
- Game: Purdue at Michigan State
- When: Friday, Nov. 22
- Where: Spartan Stadium in East Lansing, Mich.
- Time: 8 p.m. ET
- TV: FOX
- Series record: Michigan State leads the all-time series 36-29-3
- Last matchup: Purdue defeated Michigan State 40-29 on Nov. 6, 2021
Week 14
- Game: Purdue at Indiana (Old Oaken Bucket game)
- When: Saturday, Nov. 30
- Where: Memorial Stadium in Bloomington, Ind.
- Time: To be determined
- TV: To be determined
- Series record: Purdue leads the all-time series 77-42-6
- Last matchup: Purdue defeated Indiana 35-31 on Nov. 25, 2023